KMID : 0895820130230030055
|
|
Journal of Oriental Rehabilitation Medicine 2013 Volume.23 No. 3 p.55 ~ p.68
|
|
Effects of Yuhyangjeongtong-san on the Carrageenin-induced Acute Inflammation and Adjuvant-induced Arthritis
|
|
Ahn Hee-Bin
Jeong Su-Hyeon Kim Soon-Joong Park Dong-Su Seo Il-Bok
|
|
Abstract
|
|
|
Objectives: This study was to investigate the effects of Yuhyangjeongtong-san on the carrageenin-induced acute inflammation and adjuvant-induced arthritis in rats.
Methods : Acute inflammation was induced by injection of 2% carrageenin 0.15 ml into right hind foot of rats. Control group was carrageenin injected and taken distilled water, treated group was carrageenin injected and taken Yuhyangjeongtong-san by orally once. 2 hours after injection, plantar temperature and paw volume were measured. 3 hours after, counts of white blood cell (WBC) were performed. Arthritis was induced by injection of complete freund¡¯s adjuvant (CFA) into base of tail. Control group was CFA injected and taken distilled water, treated group was CFA injected and taken Yuhyangjeongtong-san by orally for 10 days. 0,5,10 day, body weight, thickness of ankle joint and paw edema were measured. 10 day, counts of WBC, interleukin-1¥â (IL-1¥â) and tumor necrosis factor-¥á (TNF-¥á) level were analysed. Histochemical study of NADPH-d and immunohistochemical study of c-fos were performed.
Results : In the carrageenin-induced acute inflammation, neutrophils of treated group were significantly decreased compared with control group. In the adjuvant-induced arthritis, paw edema, total counts of WBC and TNF-¥á level in paw exudates were significantly decreased compared with control group, and the number of c-fos positive neurons of treated group was significantly decreased compared with control group.
Conclusions : On the basis of these results, we concluded that Yuhyangjeongtong-san have anti-arthritic and anti-inflammatory effects.
|
|
KEYWORD
|
|
Yuhyangjeongtong-san, c-fos, Adjuvant arthritis
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|